Not all stem cells are completely blank slates. Some, known as adult stem cells, have already partially embraced their fates, and are capable of becoming only cells of a particular type of tissue. So how do these tissue-specific stem cells restrict their fate? In research to appear in the March 20 issue of Cell, scientists at Rockefeller University have uncovered a gene control mechanism that guides the development and differentiation of epidermal skin stem cells in mouse embryos, and shown that this mechanism tempers the development of the skin barrier.

The work, led by Elaine Fuchs, head of the Laboratory of Mammalian Cell Biology and Development, and first author Elena Ezhkova, a postdoc in the lab, highlights the interactions between genetic and epigenetic regulators in embryonic skin stem cells and how these interactions change as stem cells begin the process of specialization. The findings also provide insights that could lead to therapeutic advance in treating prematurely born infants who have not yet fully formed the skin.

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02 Protein That Controls Access To Genes Plays An Important Role In Embryonic Skin Stem Cells

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